Frontispiece: Targeting G‐Rich DNA Structures with Photoreactive Bis‐Cyclometallated Iridium(III) Complexes
نویسندگان
چکیده
منابع مشابه
Structures of protein targeting complexes
Cotranslational translocation of proteins across or into membranes is a vital process in all kingdoms of life. It requires targeting of the translating ribosome to the membrane by the signal recognition particle (SRP), an evolutionary conserved ribonucleoprotein particle. SRP recognizes signal sequences of nascent protein chains emerging from the ribosome. Subsequent binding of SRP leads to pau...
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DNA secondary structures containing regions of single-stranded DNA have now been identified in the genomic DNA of a number of prokaryotic and eukaryotic species, including humans. Many of these secondary structures are associated with regions of DNA involved in regulation of transcription: promoters or upstream elements. The secondary structures involved appear likely to be hairpin or cruciform...
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Unique properties of metal complexes, such as structural diversity, adjustable ligand exchange kinetics, fine-tuned redox activities, and distinct spectroscopic signatures, make them exciting scaffolds not only for binding to nucleic acids but increasingly also to proteins as non-traditional targets. This feature article discusses recent trends in this field. These include the use of chemically...
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We have determined two different structures of PcrA DNA helicase complexed with the same single strand tailed DNA duplex, providing snapshots of different steps on the catalytic pathway. One of the structures is of a complex with a nonhydrolyzable analog of ATP and is thus a "substrate" complex. The other structure contains a bound sulphate ion that sits in a position equivalent to that occupie...
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If L is a finite lattice, we show that there is a natural topological lattice structure on the geometric realization of its order complex ∆(L) (definition recalled below). Lattice-theoretically, the resulting object is a subdirect product of copies of L. We note properties of this construction and of some variants, and pose several questions. For M3 the 5-element nondistributive modular lattice...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2019
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201985563